Any Medical Review Show Chondrotin Works for Osteoarthritis
The Australian Rheumatology Association this week warned people not to take the supplement glucosamine for their osteoarthritis due to possible allergic side-effects.
What's the evidence backside this latest communication? And do you really need to stop taking it?
How did we get here?
For years, glucosamine has been marketed as a handling for osteoarthritis, which can occur when the protective cartilage in the joints wears downwardly over fourth dimension.
This is despite conflicting show on whether the supplement works. Even so many patients may buy glucosamine, presuming that even if it doesn't aid, at least it'south "natural" and and so won't do whatever harm.
Only an Australian study, which has been online since final year and was cited in one of this week'due south media reports, has given us more information nearly glucosamine's safe.
The study found hundreds of allergic reactions to glucosamine have been reported to Australia'due south medicines watchdog, the Therapeutic Appurtenances Administration (TGA).
So is it safe for yous to take glucosamine? In brusque, if information technology works for you and you haven't had any side-effects, and your doctor and pharmacist know you are taking it, it is probable to exist prophylactic based on the multiple trials conducted to appointment.
What is glucosamine?
Glucosamine is a naturally occurring substance the trunk uses to assistance build joint tissue, such equally cartilage and tendons. In a supplement, the glucosamine can be made from the shells of prawns and other crustaceans, or it can be made synthetically in a factory.
Whether it works to manage osteoarthritis seems open to debate. The well-nigh recent show suggests little to no clinical do good.
Merely communication to GPs about how to treat osteoarthritis says the issue isn't only bars to glucosamine.
When the Royal Australian College of General Practitioners looked at about 62 other medicines and possible treatments for osteoarthritis of the knee and hip (which include registered drugs and complementary medicines), none were backed past high-quality evidence to say they worked. Virtually of the evidence was based on low- or very depression-quality studies.
Is glucosamine really as dangerous equally people say?
The Australia study found 336 cases of side-effects to glucosamine (and to some other supplement used for osteoarthritis called chondroitin) were reported to the TGA over eleven years. Of these, 263 cases were allergies, which ranged from mild to severe.
We don't know if these reactions included those from people with a known allergy to seafood or sulfur, as these would increase their risk of a reaction to glucosamine (glucosamine tin come up in different formulations, including glucosamine sulfate).
But a large percentage of people accept glucosamine daily in Australia, with no sick effects. The cases reported to the TGA amount to just thirty people a yr, with 16% of allergic reactions considered severe.
Across allergic reactions, there are other prophylactic concerns nigh glucosamine.
For instance, if you are taking glucosamine and a medicine that thins your claret (such as warfarin after a stroke), this can increment your risk of haemorrhage.
Glucosamine supplements have likewise been implicated in chronic liver illness and in worsening underlying asthma. Some patients may also experience digestive symptoms such as heartburn.
The risks of other side-effects seem unclear, including whether information technology raises blood glucose levels in people with or without diabetes.
Conflicting advice
While the Australian Rheumatology Clan has warned people to stop taking glucosamine, other advice is not and then lucent.
Arthritis Commonwealth of australia reports glucosamine is a relatively safe treatment option for people with osteoarthritis and has relatively few side-effects compared with traditional medicines.
And the guidelines for GPs on how to manage osteoarthritis of the knee joint and hip makes a "conditional" recommendation non to apply it, based on dubiousness over the residue of harms with potential do good.
And so, what should I do?
What should you do if you lot're taking glucosamine? If it works for you and you lot want to keep using information technology, then practise so only on the advice of your doctor. That's especially the case if you lot take any underlying medical conditions including diabetes, allergies or asthma.
Next, let your chemist know so they can check for any possible interactions with your other medicines, which tin can increase your adventure of side-effects. You are near at adventure if you are also taking warfarin, or any other type of claret thinning medicine.
Finally, if you do have unwanted side-effects from glucosamine, stop using it immediately and report information technology to your doctor.
This article is republished from The Chat under a Creative Commons license. Read the original article.
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